Posted in: information, instrument

Fourteenth Five-Year Start! 600 million national funds to support scientific instruments and reagents

5 month 18 day,”Basic scientific research conditions and research and development of major scientific instruments and equipment” key special project application guidelines were released.

In order to implement the deployment arrangements for national science and technology innovation during the 14th Five-Year”Major scientific instrument and equipment research and development” key special project. According to the deployment of key special implementation plans, the 2021 annual project application guidelines are now released.

The overall goal of this key special project is to strengthen the construction of China’s basic scientific research conditions guarantee capacity, strive to improve scientific research reagents and laboratory animals Independent R&D and innovation capabilities of scientific research methods and method tools such as, scientific data, etc.; centering on the major strategic needs of national basic research and scientific and technological innovation, take the localization of key core components as a breakthrough, and focus on supporting the engineering development of high-end scientific instruments And application development, Develop high-end scientific instruments that are reliable, durable, easy to use, and users are willing to use, and effectively improve the independent innovation capability and equipment level of scientific instruments in China, promote industrial upgrading and development, and support innovation Drive the implementation of development strategies.

2021 The annual guide deployment revolves around scientific instruments, scientific research reagents, laboratory animals and scientific data It is planned to support 39 projects in four directions, and plan to arrange the state-appropriated budget of 5.39 billion yuan. In addition, it is planned to support 16 projects for young scientists, and it is planned to arrange a state-appropriated budget of 4800 million yuan, and each project will be 300 million yuan. yuan. The ratio of self-raised funds to state-appropriated funds for various scientific instruments projects shall not be less than 1:1. The project shall be declared according to the research direction of the second-level title of the guide (such as 1.1). Under the same guidelines, in principle, only 1 items are supported. Only when the application project review results are similar and the technical routes are obviously different, the 2 items can be supported at the same time, and dynamic adjustments can be established. Mechanism, based on the results of the mid-term evaluation, and then select the best to continue to support. Except for special instructions, all projects should be declared as a whole, and all research content and evaluation indicators must be covered. The project execution period is in principle 3~5 years. The number of topics under the general project does not exceed 5 , and the number of project participants does not exceed 10 . The project has 1 heads, and each project has 1 heads. The two parts of the guidelines for scientific research reagents and scientific instruments (except 5.1 ) must be jointly declared by scientific research institutions and enterprises engaged in production and sales in related fields to establish a combination of production, learning, research, and use Innovative team. The Young Scientist Project (marked after the project name) supports young researchers in undertaking national scientific research tasks. The Young Scientist Project no longer has a topic, and the total number of participating units in the project does not exceed 3 families. The project has 1 project leaders, and the young scientist project leader’s age requirements, male should be 1983 year 1 month 1 For females born after span> 1981, women should be born after 1 month 1 day. In principle, the age requirements of other team members are the same as above.

In the process of special implementation, experimental animals and animal experiments shall be abided by the laws, regulations, technical standards and Relevant regulations require the use of qualified laboratory animals to conduct animal experiments in qualified facilities to ensure that the experimental process is legal, the experimental results are true and effective, and the laboratory animal welfare and ethical review are passed. Those involved in high-level pathogenic microorganism experimental activities must meet the relevant requirements of the national pathogenic microorganism laboratory, and have the experience and guarantee conditions for conducting relevant research. Scientific research involving human subjects and human genetic resources must comply with my country’s”Regulations on the Management of Human Genetic Resources of the People’s Republic of China”,”Measures for the Ethical Review of Biomedical Research Involving Humans”, and”Guiding Principles for Human Embryonic Stem Cell Research Ethics” and other laws, regulations, Ethical guidelines and related technical specifications.

This special project 2021 annual project application guidelines are as follows.

1 High-end general scientific instrument engineering and application development p>

1.1 Glow Discharge Mass Spectrometer

Research content:for the detection of main components, trace and trace elements in high-purity materials, high-temperature alloys, insulating solid samples and other materials, as well as for material de-layer analysis ,

Inspection of depth distribution of material elements, surface analysis of coating materials, etc., break through the requirements of DC glow discharge ion source and insulating solid Key technologies such as two-cathode system, high-resolution electromagnetic double-focus mass analyzer, Faraday cup and electron multiplier tube double detector, etc., develop glow discharge mass spectrometer products with independent intellectual property rights, stable and reliable quality, and localized core components. Development related Software and database, carry out engineering development, application demonstration and industrialization promotion, realize the application in the field of semiconductor, high-purity rare earth, high-temperature alloy and other materials science research.

Assessment indicators:quality analysis range (4~250)amu ; Mass analysis stability≤25ppm/8h; resolution LR300/MR4000/HR10000; average background≤0.5cps; sensitivity≥ 1×109cps ; abundance sensitivity≤ 20ppb ; principal component repeatability≤ 3%RSD; trace component repeatability≤< span>5%RSD; Trace component repeatability≤10%RSD. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

1.2 The third generation gene sequencer

< p style="line-height:1.75em; text-indent:2em;">Research content:for DNA gene sequencing without amplification, long read direct sequencing,

Large-capacity biometric information acquisition and other testing needs, breaking through DNA precise long-read length direct sequencing, very weak light or very weak Electric signal measurement and other key technologies, develop third-generation gene sequencers with independent intellectual property rights, stable and reliable quality, and localization of core components, develop relevant software and databases, carry out engineering development, application demonstration and industrialization promotion, and realize in-gene Applications in the fields of engineering, virus detection, biosafety testing, in vitro diagnostics, etc.

Assessment indicators:average sequence read length≥15kb; longest read length≥500kb ; The highest accuracy rate of DNA direct sequencing ≥95%; sampling rate ≥1kHz; single channel sequencing speed ≥400nt /s; Traceable quantitative value determination and quality evaluation methods ≥3 species; Genome alignment consistency ≥99%; Assembly continuity NG501M bases; structural variation detection accuracy and detection rate≥90% (fragment length≥50bp). When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

1.3Ultra-high resolution live cell imaging microscope

Research content:Aiming at the detection requirements of real-time observation of the dynamic changes of the fine structure of living cells, breakthrough ultra-high resolution live cell imaging microscopy and precision opto-mechanical control , Real-time image processing and imaging calibration and other key technologies, develop ultra-high resolution live cell imaging microscope products with independent intellectual property rights, stable and reliable quality, and localized core components, develop related software and databases, and carry out engineering development, application demonstration and industry Chemical promotion to achieve applications in the fields of cytology, microbiology, biophysics and pharmacology. Assessment indicators:field of view≥10µm×10µm; horizontal resolution≤150nm; vertical resolution≤350nm; Time resolution ≥15 frame/second (2D imaging); Time resolution ≥8 frame / seconds (3D imaging). When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

1.4NMR spectrometer

Research content:For the detection requirements of chemical analysis, biomolecular structure, metabolic mixture components, etc., break through the design and manufacture of ultra-high field steady-state magnets, and high-precision magnets Resonance spectrometer control, high-efficiency radio frequency excitation and reception and other key technologies, develop nuclear magnetic resonance spectrometer products with independent intellectual property rights, stable and reliable quality, and localized core components, develop related software and databases, and carry out engineering development, application demonstration and industry Chemical promotion to realize applications in the fields of chemistry and chemical engineering, life medicine, food and pharmaceuticals, and environmental energy.

Assessment index:magnetic field strength≥14T; room temperature aperture≥50mm ;Magnetic field stability≤9Hz/h; Magnetic field uniformity≤0.05ppm; Support multi-nuclides spectrum analysis range 1H13C , 15N, 31P, 129Xe , etc.; RF bandwidth 50~650MHz and above; spectrum frequency resolution Rate ≤0.003Hz; number of RF transmitting channels ≥2 channels; liquid helium replenishment time ≥150 days. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

1.5Broadband sampling oscilloscope

Research content:Development and testing of broadband analog circuits and high-speed digital circuits for 5G mobile communications, optical fiber communications equipment and high-speed network equipment Demand, breakthrough 85GHz sampler, ultra-low jitter clock generation and triggering, high-speed clock recovery, high-precision waveform acquisition and recovery, signal integrity analysis and other key technologies, develop independent intellectual property rights, stable and reliable quality , Broadband sampling oscilloscope with core components made in China, develop related software and database, carry out engineering development, application demonstration and industrialization promotion, realize the realization in optical fiber communication, 5G mobile communication, radar, satellite communication and Applications in satellite navigation and other fields.

Assessment indicators:electrical sampling module:number of channels 2; test bandwidth ≥85GHz< /span>; sampling rate ≥150kSa/s; jitter ≤80fs; sampling resolution 16bit; optical sampling module:wavelength range 800~1600nm; optical receiving sensitivity is better than -7dBm; test bandwidth≥ 65GHz; sampling rate≥150kSa/s; jitter ≤250fs; sampling resolution is 16bit. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

1.6Highly sensitive chiral substance ion mobility spectrometer combined with mass spectrometer strong>

Research content:rapid chiral molecular isomers for biological sample analysis, clinical diagnosis and drug development Recognition, high sensitivity and high accuracy quantitative analysis requirements, breakthrough ion migration process model simulation and control, preparation of highly selective reagents for chiral substances, efficient and selective storage of chiral gas phase ions, high-resolution chiral gas phase ion configuration difference analysis and quality Analysis and other key technologies, develop a highly sensitive chiral ion mobility spectrometer and mass spectrometer with independent intellectual property rights, stable and reliable quality, and localization of core components, develop related software and databases, and carry out engineering development, application demonstration and industrialization Promote and realize the application in the fields of life science, clinical medicine and pharmacology.

Assessment indicators:chiral molecular purity detection range 0.1%~99.9%, ion mobility spectrum resolution Rate ≥300; detection limit of chiral substance analysis ≤10-10mol/l; mass resolution of mass spectrum ≥100000< /span>; Chiral molecule analysis time≤10 min/ samples; establishment of chiral material database 1 set. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

1.7Complicated microstructure three-dimensional optical microscope measurement instrument p>

Research content:For photodetectors, MEMS microsystems, semiconductor integrated circuits and other micro devices and optics Device surface and sub-surface defect detection requirements, breakthrough high-slope smooth microstructure, deep V structure, mixed material laminated microstructure, laminated structure subsurface and other complex microstructure three-dimensional geometric shape characterization, three-dimensional geometric parameters precision Key technologies such as measurement, sub-surface defect detection, etc., develop complex microstructure three-dimensional optical microscope measuring instruments with independent intellectual property rights, stable and reliable quality, and localization of core components, develop related software and databases, and carry out engineering development, application demonstration and industry It can be promoted to achieve applications in the fields of ultra-smooth optical surface damage, semiconductor integrated circuits, optoelectronic integrated circuits and other fields.

Assessment index:Microscopic field of view ≥100μm× 100μm; horizontal surface microscopy resolution≤250nm; horizontal subsurface microscopy resolution≤400nm span>; vertical resolution≤20nm; smooth microstructure measuring tilt angle≥50°; single material step height measurement error≤5% ;Measurement error of multi-layer material step height≤10%; subsurface defect detection depth≥110μm; defect detection sensitivity≤200nm; depth positioning accuracy≤2μm; high-energy damage defect determination accuracy ≥80%. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥3000 hours, and the technical readiness is not lower than 8 ; at least it should be used in 2 fields or industries. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2 Development and application of core key components

< p style="line-height:1.75em; text-indent:2em;">In principle, the number of topics under each project should not exceed 4 , and the total number of participating units of the project should not exceed 4 , and the implementation period does not exceed 3 years.

2.1fast tunable laser

Research content:develop a tunable laser with a large wavelength tuning range and fast tuning speed, breakthrough large-scale no-hop cavity design, high-speed microcavity modulation preparation, High-speed digital laser module drive circuit design, mode compensation algorithm, wavelength nonlinear correction and other key technologies, carry out engineering development, application demonstration and industrialization promotion, form components with independent intellectual property rights, stable and reliable quality, and realize in the optical coherence layer Analytical detection, high-precision spectral analysis and confocal measurement and other instruments.

Assessment indicators:center wavelength 1060nm and 1310nm; output power ≥ 15mW; wavelength tuning range≥110nm; repetition frequency≥100kHz; coherence length≥15mm. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.2thermal field emission electron source

Research goals:develop thermal field emission electron source, breakthrough single crystal tungsten preparation, tip orientation and shape control, zirconia treatment, electron gun structure design, filament pair To carry out engineering development, application demonstration, and industrialization promotion of key technologies such as China Control, and form products with independent intellectual property rights and stable and reliable quality components, which can be used in scanning electron microscopes, transmission electron microscopes and other instruments.

Assessment index:micro-tip curvature radius range 1.2µm~0.4µm (controllable), error ≤±0.05µm; cathode temperature 1750K~1800K; grid voltage -200~-600V (adjustable); angular current density 200µA/sr; extraction voltage 3~6kV (adjustable); maximum electron beam current ≥150nA; current stability ≤1%< /span>. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.3Side-window photomultiplier tube

< p style="line-height:1.75em; text-indent:2em;">Research content:Development of high-performance side-window photomultiplier tubes with multi-alkali cathodes, a breakthrough in the preparation of wide-spectrum and high-sensitivity reflective multi-alkali photocathodes. Key technologies such as gain electron multiplier structure design, high secondary electron emission material preparation, low dark count rate and other key technologies, carry out engineering development, application demonstration and industrialization promotion, and form components with independent intellectual property rights, stable and reliable quality, and realize in the spectrum Analysis, electron microscopic analysis and X ray analysis and other instruments.

Assessment index:detection area ≥8mm×24mm; cathode spectrum Response range ≥165nm~900nm; cathode integral sensitivity ≥250μA/lm; gain ≥1×< span>107; dark count rate≤1000cps; dark current≤10nA(1000V); rise time

2.4 Magnetic resonance imaging cryogenic probe

Research content:develop magnetic resonance imaging cryogenic probes, break through key technologies such as high-density radio frequency arrays, ultra-low temperature refrigeration systems, and low-noise preamplifiers, carry out engineering development, application demonstrations and industrialization promotion, and form independent Intellectual property, stable and reliable component products, realize the application of high-field magnetic resonance imagers, spectrum analyzers and other instruments.

Assessment index:number of channels ≥2; scanning aperture ≥2cm ;RF probe matching≤-15dB; probe temperature≤30K; preamplifier noise figure≤1dB; sensitivity improvement (low temperature /Normal temperature) ≥4 times. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches the level of 9 ; at least used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

2.5X Ray energy spectrum detector

< p style="line-height:1.75em; text-indent:2em;">Research content:Development of X ray energy spectrum detector, breakthrough large-area silicon drift detection, charge pre-amplification, digital Key technologies such as multi-channel analysis, leakage current noise suppression, vacuum packaging, etc.; carry out engineering development, application demonstration and industrialization promotion; form components with independent intellectual property rights, stable and reliable quality, and realize them in X The application of ray energy spectrometer, electron microscopy energy spectrum analyzer and other instruments and synchrotron radiation large scientific devices.

Assessment index:detector size≥30mm2; energy resolution≤127eV(MnK ); detection element range Be~Am; maximum output count rate≥300kcps(maximum input count rate 1000kcps); window material Beryllium, silicon nitride (100nm) or no window. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.6High-precision Hartman-Shark wavefront sensor

Research goals:develop high-precision Hartmann-Shake wavefront sensors, and make breakthroughs in the preparation of high-quality microlens arrays, microlens arrays and detectors Key technologies such as high-precision coupling, ultra-high-precision error calibration, fast and high-precision wavefront reconstruction, etc., carry out engineering development, application demonstration and industrialization promotion, and form components with independent intellectual property rights, stable and reliable quality, and achieve high beam quality Applications in analysis, adaptive optics systems and three-dimensional measurement instruments.

Assessment index:spatial resolution ≥128×128; tilt Measurement range ≥±3°; tilt measurement accuracy ≤1μrad; relative wavefront measurement accuracy (RMS )≤λ/150; Absolute wavefront measurement accuracy (RMS)≤λ/100; Repeatability accuracy (RMS span>)≤λ/200; working wavelength range 400~1100nm; frequency ≥7Hz. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Class instrument. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.7High-throughput biological sample vacuum transfer device

Research content:develop a high-throughput biological sample vacuum transfer device, breaking through the key points such as fine manipulation of small samples, precise vacuum and low-temperature motion, and low-temperature sample coating Technology, carry out engineering development, application demonstration and industrialization promotion, form part products with independent intellectual property rights, stable and reliable quality, and realize the application in transmission electron microscope and scanning electron microscope.

Assessment index:minimum storage temperature≤-160℃; vacuum degree≤5< /span>×10-4Pa; motion accuracy≤100μm; sample storage quantity≥12grids; coating Vacuum degree≤4Pa; coating sample table temperature≤-160℃. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.8Deep ground acoustic detector

Research content:develop acoustic detectors with high temperature resistance, high pressure resistance, high performance and high stability, breakthrough high temperature and high pressure material control, small volume and low frequency Broadband structure, interface bonding mechanism and technology and other key technologies, carry out engineering development, application demonstration, and industrialization promotion, form parts with independent intellectual property rights, stable and reliable quality, and realize three-dimensional remote sound wave detectors and deep ultrasound imaging Application in logging tools and other instruments.

Assessment index:unipolar transducer (length expansion):working frequency band 5~20kHz, The highest temperature resistance≥260℃, the highest pressure resistance≥200MPa; dipole transducer (flexural vibration):working frequency band 1~4.5kHz , The highest temperature resistance≥230℃, the highest pressure resistance≥172MPa; multi-pole receiver:working frequency band 1~20kHz, the highest temperature resistance≥ 230℃, maximum withstand pressure≥172MPa; ultrasonic transducer:working frequency band250~700kHz, maximum temperature resistance≥205< /span>℃, the highest withstand voltage ≥172MPa. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Class instrument. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through trial use.

2.9THz superconducting mixer

Research content:development of terahertz superconducting mixer, breakthrough superconducting mixer chip design and preparation, superconducting mixer and low temperature Key technologies such as low-noise amplifier integration, one-dimensional coherent detection receiver array integration, etc., carry out engineering development, application demonstration and industrialization promotion, form components with independent intellectual property rights, stable and reliable quality, and realize Application in instruments such as Hertz security checker and radio astronomy receiver.

Assessment indicators:detector center frequency 0.1~0.3THz; intermediate frequency bandwidth ≥5GHz ; noise temperature≤7 times quantum noise; dynamic range≥30dB; pixel≥1×10. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥ 5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

2.10Separation Dynode Electron Multiplier

Research content:Development of a separate dynode electron multiplier, a breakthrough in the detector’s high-purity dynode alloy and film preparation, high-precision packaging, Key technologies such as safe storage in the air, pulse and analog dual-mode detection, develop components and products with independent intellectual property rights, stable and reliable quality, carry out engineering development, application demonstration and industrialization promotion, and realize the use of magnetic mass spectrometers and quadrupole mass spectrometers. Application on the instrument.

Assessment index:gain ≥105 (in simulated working state), gain ≥107 ( in pulse counting mode); dark current≤1pA; dark counting rate≤50cps; single ion pulse width/Half-height width≤7ns. When the project is completed, it has passed the reliability test and the third-party remote test. The mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

2.11Broadband coaxial probe

< p style="line-height:1.75em; text-indent:2em;">Research goal:develop a wide-band coaxial probe to break through key technologies such as heat treatment and surface treatment of elastic parts, precision micro-assembly, and processing of small parts. Carry out engineering development, application demonstration and industrialization promotion to form component products with independent intellectual property rights, stable and reliable quality, and realize the application of microwave integrated circuit on-chip tester, on-chip antenna tester, three-dimensional package antenna tester and other instruments .

Assessment index:2.92mm Connector probe:Operating frequencyDC~40GHz< /span>, insertion loss≤1.5dB; 2.4mm connector probe:working frequency DC~50GHz, insertion loss≤ 1.5dB; 1.85mm connector probe:working frequency DC~67GHz, insertion loss ≤2.0dB. When the project is completed, it has passed the reliability test and the third-party remote test, the mean time between failures is ≥5000 hours, and the technical readiness reaches 9 ; at least it should be used for 2 < /span>Like instruments. Clarify the number of intellectual property rights such as invention patents, standards, and software copyrights, and have independent intellectual property rights; form mass production capacity, and meet user requirements through user trials.

2.12 精密大带宽锁相放大器

研究目标:开发精密大带宽锁相放大器,突破大带宽数字调制、高分辨率数模转换和高精度相位解调等关键技术,开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在微弱信号探测、光谱测量及分析、电子束测量及能谱分析等仪器中的应用。

考核指标:频率范围 0~50MHz;输入电压噪声≤5nV/Hz;动态储备≥120dB;满量程输入灵敏度≤1nVA/D14bit;相位分辨率≤1μdeg;频率分辨率≤0.7μHz。项目完成时通过可靠性测试和第三方异地测试,平均故障间隔时间≥5000 小时,技术就绪度达到 9 级;至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力, 经用户试用,满足用户使用要求。

2.13相位型液晶空间光调制器

研究目标:开发相位型液晶空间光调制器,突破大相位调制深度、高帧率驱动、高抗激光损伤等关键技术,开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在光束整形仪、波分复用仪、单色仪、超快激光加工机、激光打标机等仪器设备中的应用。

考核指标:像元数≥1920×1080;相位范围≥2π(1064nm);相位灰阶≥8bit;填充因子≥92%;衍射效率≥80%;刷新频率≥ 100Hz;最大输入光功率密度≥50W/cm2。项目完成时通过可靠性测试和第三方异地测试,平均故障间隔时间≥5000 小时,技术就绪度达到 9 级;至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力,经用户试用,满足用户使用要求。

2.14 X 射线椭球聚焦镜

研究目标:开发 X 射线椭球聚焦镜,突破 X 射线椭球聚焦镜制作、性能检测、高精度装校等关键技术,开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在 X 射线衍射仪、X 射线散射仪和X 射线成像仪等仪器中的应用。

考核指标:工作能段 1~8keV;聚焦斑点≤100μm;口径≥15mm;聚焦镜长度≥30mm;镜面表面粗糙度≤0.5nmrms);反射率≥70%。项目完成时通过可靠性测试和第三方异地测试, 平均故障间隔时间≥5000 小时,技术就绪度达到 9 级;至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力,经用户试用,满足用户使用要求。

2.15双频短相干激光光源

研究目标:开发双频短相干激光光源,突破激光线宽调制、高稳定低频差调制、高精度光程匹配与高效率耦合等关键技术, 开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在任意曲面测量、大口径干涉测量和平面干涉测量等仪器中的应用。

考核指标:中心波长 633nm;相干长度≤300µm;功率≥1mW(单模光纤输出);双频频差 5Hz 10Hz;频差不稳定度≤1%;光程匹配范围≥100mm。项目完成时通过可靠性测试和第三方异地测试,平均故障间隔时间≥5000 小时,技术就绪度达到 9 级; 至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力,经用户试用, 满足用户使用要求。

2.16高稳定度高压电源

研究目标:开发高稳定度高压电源,突破高电压长时间稳定

控制、低纹波噪声抑制和低温度漂移控制等关键技术,开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在电子显微镜、离子显微镜等科学仪器中的应用。

考核指标:加速电压-20V~-35kV(可调),纹波≤20mV,稳定性≤10ppm/15 分钟;抑制级电压-200V~-1kV(可调),纹波≤ 15mV,稳定性≤10ppm/15 分钟;引出级电压:1kV~6kV(可调),纹波≤15mV,稳定性≤10ppm/15 分钟;灯丝电源电流 0~3A(可调)、电压 0~5V(可调),电流稳定性≤0.5mA/1 小时。项目完成时通过可靠性测试和第三方异地测试,平均故障间隔时间≥5000 小时,技术就绪度达到 9 级;至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力,经用户试用,满足用户使用要求。

2.17 多通道可变分辨率数据采集卡

研究内容:开发高速数据采集卡,突破高密度多通道隔离设计、多通道同步采集和噪声抑制等关键技术,开展工程化开发、应用示范和产业化推广,形成具有自主知识产权、质量稳定可靠的部件产品,实现在超声检测仪、电子显微镜、扫描探针显微镜等仪器中的应用。

考核指标:采集通道单端 16 /差分 8 路,每通道采样率和分辨率可设置;采样率 50kSa/s,分辨率 24bits,噪声电平 3.4μVrms;采样率 500kSa/s,分辨率 24bits,噪声电平 4.3μVrms;采样率1MSa/s,分辨率 22bits,噪声电平 13μVrms;采样率 5MSa/s,分辨率 20bits,噪声电平 31μVrms;采样率 10MSa/s,分辨率 18bits, 噪声电平 92μVrms;采样率 15MSa/s,分辨率 16bits,噪声电平401μVrms。项目完成时通过可靠性测试和第三方异地测试,平均故障间隔时间≥5000 小时,技术就绪度达到 9 级;至少应用于 2 类仪器。明确发明专利、标准和软件著作权等知识产权数量,具有自主知识产权;形成批量生产能力,经用户试用,满足用户使用要求。

3 高端化学试剂研制

3.1高端金属与配体试剂制备关键技术研发

研究内容:开展广泛应用于偶联、氧化、还原、加成、聚合反应的金属试剂(钌、铑、钯、铱、铂、铜、镍、铬、锰、铁、钴、锂及其各种价态的金属试剂)的制备方法和批量生产技术研究,研发具有自主知识产权的金属试剂;发展并建立具有重要应用价值的配体,特别是手性配体(含磷、氮、氧、硫配位原子的手性配体、手性烯烃配体和卡宾配体)的高效合成方法和批量制备技术,以及研发基于研究基于上述配体的新型高效金属催化剂, 开展其在化学、化工、医药以及新材料中的应用示范研究。

考核指标:建立高端金属试剂、配体试剂自主知识产权体系,申请专利 20 项以上,实现重要金属试剂、催化剂以及配体的批量制备能力,包括 1)建立 50 个以上高纯(≥99%)金属试剂百克级规模的制备技术和质量控制标准;2)建立 100 个以上高纯手性配体和手性催化剂(纯度≥99%,≥99%ee)的克级规模的 制备技术和质量控制标准,形成 5 项以上企业或行业标准,并研发 15 个以上具有自主知识产权的手性配体和手性催化剂。

3.2有机氟试剂研制

研究内容:利用我国储量丰富的氟资源(萤石),研发新型亲电/亲核氟化、氟烷基化、氟烯基化、氟烷杂基化、[18F]同位素标记氟化试剂,开发具有我国自主知识产权的氟化学试剂,发展经济可行性好的合成工艺,实现原创试剂的批量化制备,并建立高纯氢氟酸的制备方法,把资源优势转化为技术优势,并利用原创性试剂,有力促进催化科学、含氟新材料和药物等方面的创新研究。

考核指标:建立系列氟化学试剂的合成方法,形成 40 个以上具有自主知识产权的氟化、氟烷基化、氟烯基化、氟烷杂基化试剂(纯度≥99%)的批量制备技术并实现商品化,研发的试剂 列入国内外知名试剂销售商的产品目录,实现在国内外销售,催生 15~20 项原创性氟化、氟烷基化、氟烯基化、氟烷杂基化新技术;突破 8~10 项基于氟化试剂的[18F]标记探针(丰度≥90%,纯度≥99%)的合成技术;建立氟化学试剂从原料、合成、工艺到产品全流程自主知识产权体系,申请专利 15 项以上,实现高纯氢氟酸和若干重要氟化学试剂的批量制备能力,并制定质量控制标准。

4 应用于重大疾病诊断的生物医学试剂创制与应用

4.1近红外活体荧光成像诊断试剂体系研究开发

研究内容:针对恶性肿瘤、心脑血管等重大疾病的早期精准诊断挑战,根据特异性标志分子、病理微环境特性等,发展高特异性抗体及抗体导向的响应近红外荧光成像试剂,建立高组织穿透深度、高时空分辨率、高灵敏的诊断技术方法,揭示重大疾病的发生发展机制;开发系列诊疗一体化近红外荧光成像试剂,实现在“可视化”药物筛选与评价、光热与光动力治疗、免疫治疗、荧光指导的手术导航等领域的应用;建立红外二区荧光成像试剂的安全性评价方法和标准化、规模化制备方法与流程,推进临床转化。

考核指标:建立近红外荧光成像材料的可控制备技术,研发4~6种高性能近红外成像材料(含有机分子、稀土材料、量子点、荧光蛋白等)并实现百克级量产,发光波长达1000~1700纳米, 荧光量子效率>20%;研发5~8种重大疾病靶向的特异性抗体,并实现与荧光材料的耦联,发展高性能近红外荧光成像试剂,实现生物组织穿透深度>1.8cm;对

4.2先进高场磁共振设备高分辨影像试剂研究开发

研究内容:拟针对现有磁共振诊断试剂在高场下灵敏度低的难题,研发具有原始创新性的先进高场磁共振影像试剂,发展在体、实时、无创成像的新技术;为国产高端磁共振设备提供具有完全自主知识产权的高分辨率影像试剂,实现高场磁共振影像在生物医学应用的新突破,满足重大疾病微小病灶早期成像以及疾病区域血管等精细组织成像的重大需求;建立评估高场磁共振诊断试剂的生物安全性评价机制,建立试剂量产质控体系和标准品, 推进其向临床转化。

考核指标:研发3~5种高性能磁性纳米材料并实现公斤级量产,在7T以上的高场条件下,试剂的横向弛豫率与纵向弛豫率比值(r2/r1)≤2;试剂在水相中保持稳定分散时间不少于1年。作为高场磁共振影像试剂,其在磁共振成像应用中应达到接近组织病理学检测水平的诊断灵敏度,实现接近组织病理学检测水平的诊断灵敏度,对

5 同位素试剂

典型同位素试剂研发与科研试剂评价技术标准研究

研究内容:建立稳定可控的同位素试剂制备流程,开展制备方法标准化和程序化研究,进行产品重现性和稳定性的测试,研究高丰度无机同位素试剂制备和丰度测量技术;研究以13C2H 同位素标记为代表的系列有机同位素标记物的共性制备、纯化和测量技术,开发2H 13C 标记同位素标记物;研究基于13C15N 稳定同位素标记的新型大分子同位素标记物;研制基于核反应堆和回旋加速器的放射性同位素试剂及溶液标准物质;研制高纯试剂、同位素试剂、生化试剂等的质量评价技术体系,包括质量评价共性技术方法、评价用质控物质,和评价规程规范。

考核指标:制备无机同位素试剂 8 种,每种至少 1 克,总量不低于 50 克,丰度≥90%,纯度≥99%;开发食品环境检测用2H13C 取代同位素标记物17~20 种,各1 克,丰度≥98%,纯度≥98%,或不低于进口产品;核设施安全运行监测用 8 种放射性同位素质控物质,不确定度优于 1.5%,单种放射性同位素产能 3.7E11 Bq/年,γ放射性不纯度13C15N 稳定同位素标记大分子同位素标记物 2 种;建立同位素试剂检测方法 12~15 种; 高纯试剂、同位素试剂、生化试剂等共性关键指标评价技术方法20 种、评价用参考物质 30 种、规程规范 8~10 项,建立科研试剂质量评价技术体系 1 套,开展重点领域科研试剂质量评价示范应用 10~15 次。

6 人类疾病动物模型创制研究

6.1人类重大传染病基因修饰动物模型研发

研究内容:针对 SARS-CoV-2SARSMERSH7N9Zika等病毒感染造成的人类重大传染病,研究以小鼠和大鼠等动物为主要实验载体的基因编辑动物模型的创新技术体系,研发一批适用于对某类(些)疾病发生机制进行多维度解析和新药研发与安全性评价等领域有重要应用价值的系列化基因编辑动物模型。开展基因编辑动物模型表型分析与评价技术平台建设的研究,以及病理学图谱的研究。开发相应疾病动物模型数据库和动物资源库, 为阐明相关疾病发病机制、验证新的药物靶标和新药开发与疫苗评价等提供基础条件。

考核指标:建立完整的以小鼠和大鼠等动物为主要实验载体的基因编辑动物模型创新技术。完成 10~15 种符合人类重大传染病临床特征的新型基因修饰动物模型。建立和完善与这些疾病相关的动物生理生化、组织功能、动物行为学及免疫学检测技术和表型分析方法,以及动物模型技术指标体系和评价技术平台。完成描述和绘制新建人类重大传染病动物模型的动态演变规律和靶器官细胞分子演化图谱,以及不同阶段典型的病理学图谱,揭示其生理和病理意义。建立相关疾病动物模型数据库和生物学数据库。完成新建疾病动物模型相关的专利申报,并实现创建的新型疾病动物模型与现有国家实验动物资源库的整合。

6.2心血管、代谢性疾病等基因修饰动物模型研发

研究内容:针对人类心血管(冠心病、心肌梗死、心力衰竭、高血压、心肌缺血/再灌注损伤等)、代谢性(肥胖、糖尿病、非 酒精性脂肪肝病等)疾病等严重危害人民健康的重大疾病,研究以小鼠和大鼠等动物为主要实验载体的基因编辑动物模型的创新技术体系,研发一批适用于对某类(些)疾病发生机制进行多维度解析和新药研发等领域有重要应用价值的系列化基因编辑动物模型。建立动物模型制备技术体系,开展基因编辑动物模型表型分析与评价技术平台建设的研究。利用所研发的疾病动物模型, 深入研究主要心血管和代谢性疾病的发生机制,开发关键治疗靶点。建立相关疾病动物模型不同阶段典型的病理学图谱,揭示其生理和病理意义。开发相关疾病动物模型数据库、样本资源库和生物数据库。

考核指标:建立多位点、多易感动物基因的疾病动物模型和完整的动物模型制备技术体系,完成以小鼠和大鼠等动物为主要实验载体的 50 种人类心血管和代谢性疾病等基因编辑动物模型。完成不少于 50 种疾病动物模型评价流程、技术指标体系及评价技术平台,以及不同阶段典型的病理学图谱,揭示其生理和病理意义。利用新建疾病动物模型研究 30 种以上主要心血管和代谢性疾病的发生机制,发现 20 个以上关键药物靶点。建立疾病动物模型数据库和模型资源库,以及相关疾病动物模型的生物数据库。完成新建疾病动物模型相关的专利申报,实现创建的新型疾病动物模型与现有国家实验动物资源库的整合。

6.3基于特色实验动物的人类疾病动物模型创建及关键技术研究

研究内容:在已建立的长爪沙鼠、东方田鼠、裸鼹鼠、高原鼠兔、树鼩、非人灵长类等动物的标准化种群基础上,选择已有较好研究基础和重要应用潜质的动物开展人类疾病动物模型的研究。重点支持利用基因编辑、物理干预、化学诱导等技术,研究病因性阿尔茨海默症、帕金森病、代谢性紊乱、辐射损伤、脑缺血、血吸虫病等动物模型。解决利用这些特色动物创制人类疾病动物模型的关键技术难点,建立疾病动物模型评价体系,系统描述和绘制疾病动物模型病理学图谱,开发疾病动物模型数据库。

考核指标:根据选定的研究目标、研究技术和特色实验动物种类,完成 4~6 种人类疾病动物模型的制备,建立完善的动物模型的创制技术和评价技术体系。完成相关疾病动物模型不同阶段典型的病理学图谱。完成新建疾病动物模型相关的专利申报或新种鉴定,实现新建疾病动物模型与现有国家实验动物资源库的整合。

有关说明:本方向拟支持不超过 6 个项目。

7 国家实验动物资源库服务质量提升

国家实验动物资源库服务科技创新能力提升关键技术研究与示范

研究内容:以国家实验动物资源库已有资源和已建立标准化种群的实验动物新品种新品系为主要对象,开展遗传选育、资源保藏、生物净化、品种品系鉴定等技术,以及相关生物学特性深度挖掘、数字化描述和数据汇交等方面的研究;开展实验动物新资源创建关键核心技术研究,利用具有较好前期研究基础和重要应用潜质的资源动物,采用动物种群生物学和种群基因组学技术培育实验动物新品种新品系。研发符合标准要求的规模化生产关键技术,形成具有一定规模的保藏与供应的实验动物资源平台, 提升国家实验动物资源平台技术能力和资源共享服务水平。

考核指标:建立完善的 SPF 级实验动物的遗传育种、资源保藏和生物净化等技术体系、实验动物新品种新品系的鉴定技术体系和技术平台。完成培育不少于 10 种实验动物新品种新品系, 并建立SPF 实验动物种群。完成不少于 20 个实验动物品种品系生物学特性的数字化描述,建立不少于 5000 个生物学特性指标的数据库。国家实验动物资源库与其他资源保藏机构共同构成的资源平台,所保藏与共享服务的实验动物资源种类覆盖我国常用实验动物品种品系 80%以上,供种满足率达到 70%以上。实现不少于 5 种具有自主知识产权的实验动物新品种新品系与现有国家实验动物资源库的整合。

8 实验动物质量评价

实验动物质量评价关键技术研究(青年科学家项目) 研究内容:参照国际先进的实验动物质量标准,研究实验动物微生物和寄生虫的病原/抗体检测方法;研究常用实验动物 SNP等遗传质量检测技术;建立针对病原微生物和寄生虫的特异、敏感、稳定的病原/抗体检测方法和相关技术规范;研制假病毒库, 建立实验动物免疫后中和抗体评价方法和技术规范;建立达到国际先进水平、适于自动化操作的封闭群和近交系实验动物 SNP 等遗传检测方法体系。所有新建检测方法技术指标(敏感性和特异性等)符合相关标准或技术指南要求。

考核指标:由申报单位自主设定。

实验动物病原快速检测新技术研究(青年科学家项目) 研究内容:开展实验动物人兽共患病、烈性传染病、新发和再发传染病的分子病原学检测技术,以及高通量筛查与鉴别、基因芯片和快检技术等新技术和新方法研究;建立高通量筛查与鉴别、基因芯片和快检方法及技术规范。所有检测方法技术指标(敏感性和特异性等)符合相关标准或技术指南要求。

考核指标:由申报单位自主设定。

9 科学数据分析挖掘应用关键技术与软件系统

9.1 生物大数据管理和分析关键技术与系统

研究内容:面向生物大数据管理、深度挖掘和转化应用等核心技术方面的短板,研发生物大数据汇交质控、发布更新等全生命周期的智能化管理系统;研究基于海量大数据的基因组序列精准定位、生物信息库多源融合及跨库检索等关键方法;建立生物大数据与文献信息关联融合机制,研发海量生物文献关键信息提取及其与数据共享互联的关键技术;优化现有基因组变异演化分析等生物信息学方法,建立对基因组重要功能位点突变的快速自动化监测和基于基因型网络推演重大疾病感染途径及传播路径的实时智能追踪系统;建立人工智能网络模型,开展肿瘤和心脑血管等疾病演变模式分析,实现疾病精准诊断、个体化治疗和健康管理等重大临床需求。

考核指标:形成具有PB 级数据处理能力的生物大数据智能化管理系统等应用软件 5 项以上、基于海量大数据的基因组序列精准定位等分析挖掘的关键算法 5 项以上;形成生物信息库多源融合及具有上亿条记录处理能力的跨库检索等关键方法 2 项以上;研发 2~3 种肿瘤和心脑血管疾病全景式演变模式的人工智能分析模型;在国家生物类科学数据中心开展战略生物资源、人类遗传资源方面的应用,部署 100 种以上生物信息软件和流程,关联 100 个以上生物信息数据库,集成不少于 50PB 的组学原始数据等各类生物学数据;形成生物数据管理和分析的专利或软件著作权。

9.2 微生物科学数据管理与挖掘关键技术与应用

研究内容:研究以微生物科学数据为重点的微生物数字信息管理、汇聚、共享和安全保障的数据治理技术体系,研究微生物菌、毒种标本、样本的图像、图谱、序列等信息数据的高效识别与实时处理技术,建立符合国际标准的新型智能管理软件系统; 研发针对海量微生物相关科学数据的加密与脱敏软件工具;研究微生物表型、基因型、免疫性、形态图谱等数字资源整合与挖掘技术,研发智慧化微生物数据挖掘和分析模型、软件系统;研究面向海量异构微生物资源信息数据的垂直检索、关联整合与可视化技术,结合知识图谱和智能识别技术,实现基于科学数据在食品安全、口岸安全等领域的智慧化多点信息监控和应用示范。

考核指标:建立一套符合国际标准的覆盖细菌、真菌、病毒的二十种以上微生物数据的智能化整合挖掘软件系统;建立微生物资源数据治理体系、数据安全分析体系和数据安全保障技术体系,形成 3~5 项微生物科学数据安全与管理标准,开发基于区块链技术的微生物数据隐私计算技术平台,支撑千万级数据的实时分析;整合新建超过 50 亿条微生物科学数据与文献数据的知识图谱,在国门生物安全、食品安全等方向建立应用示范,在金砖、一带一路沿线等不少于 30 个国家进行推广应用;围绕微生物科学数据的智能管理与挖掘应用形成一系列专利与软件著作权。

9.3 生态系统大数据智能管理与挖掘关键技术及应用

研究内容:面向我国生态文明建设国家战略,依托我国不同类型生态系统野外观测研究台站,研发耦合人工、自动等多源、高频观测数据的多层次的生态系统大数据管理软件系统;建立标准化生态台站监测数据质量控制和数据产品开发体系,研发基于工作流的生态数据产品软件工具;整合联网观测、地面调查、卫星遥感、文献等多源异构生态数据,研究多源生态数据时空挖掘、融合和数据同化技术,发展耦合人工智能和生态过程模型的生态系统质量评估模型与预测技术体系,研发生态系统大数据挖掘与预测软件系统;提高我国生态系统观测研究台站自主的数据处理分析挖掘能力,支撑我国生态文明建设。

考核指标:建立一套覆盖农田、森林、草地、湖泊等多种生态系统类型的长期生态监测数据的智能化管理系统软件,在不少于 10 个野外台站以及中亚一带一路沿线国家野外站推广示范应用;整合形成超过 30 个以上野外台站的长序列生态类监测数据产品,建立标准化的生态监测数据质控软件工具和产品开发工具, 生态系统大数据分析挖掘和预测系统 1 套,在科学数据中心部署应用,并在国家生态系统质量评估中开展示范;形成生态系统大数据挖掘与管理方面的软件著作权和专利。

9.4 场景驱动的海洋科学大数据挖掘分析关键技术与应用

研究内容:针对海洋观测、监测、调查、统计等数据的多源多维异构特征,研究海洋科学大数据存储管理、融合分析、关联挖掘等关键技术,构建大数据在线存储分析引擎;突破多源海洋环境数据的多尺度多要素同化技术,建立自主化高分辨率海洋数值模式,研制多区域、高精度、长时序的海洋环境信息产品;构建集传统统计分析方法和大数据方法于一体的海洋经济与资源环境协调发展分析和预测模型,面向空间资源开发利用、生态环境修复等典型应用场景建立知识图谱;研发集算力—数据—模型— 知识于一体的海洋科学大数据融合分析软件,在沿海地区经济布局优化、产业提质增效、资源集约利用等领域开展示范应用,提升海洋科学数据增值服务能力。

考核指标:海洋大数据在线存储分析引擎 1 套,支持超大规模数据的并发在线交互计算分析能力,集成多源要素融合、特征提取、关联分析、可视分析、统计分析、机器学习等方法算法不少于 6 种,典型分析计算响应时间不超过 5 秒;自主化海洋环境大数据超分辨率融合分析模型 1 套,中国海区 1/12°和海区 1/30° 海洋环境要素信息产品各 1 套,海洋资源和生态环境综合数据集各 1 套;建立基于大数据的海洋经济与资源环境融合分析和预测指标体系及模型各 1 套,形成海洋典型应用场景通用知识图谱构建框架,建立海洋空间规划应用、海域海岛管控与开发利用等知识图谱不少于 2 套;海洋科学大数据融合分析软件 1 套,在沿海地区开展示范应用;有关软件系统在科学数据中心得到部署应用, 形成保护相关技术方法、模型和软件的知识产权。

9.5 卫生健康科学大数据智能分析与挖掘关键技术与应用

研究内容:面向人民生命健康,研发多源卫生健康科学大数据汇聚管理、多维特征刻画、深度整合、大规模智能语义搜索和可视化关键技术,研究多病种及人群特征数据智能筛选、抽取和建模方法,研发集成疾病危险因素分析、病例跨时空分析、疾病风险预测等多种智能挖掘算法和功能的协同分析系统和系列工具;研究卫生健康科学大数据跨域、跨机构共享机制及隐私感知与计算、关联识别、自动分类和智能自适应脱敏算法以及卫生健康科学大数据安全态势感知与监测预警关键技术;研究医学影像辅助判读、临床病历智能提取和标注、多病种知识图谱自动构建关键技术,在疾病风险预测、临床辅助决策、药物不良反应监测、健康管理等领域开展应用示范。

考核指标:研发一套面向PB 级卫生健康科学大数据的智能语义搜索、高效融合、特征抽取、深度挖掘的一体化、智能化数据管理和协同分析平台,具备万级用户并发访问能力;研发大数据应用所急需的具备高扩展性、高性能的智能人群分层、特征识别、疾病风险因素挖掘分析等工具软件不少于 10 个;研发可与国际主流产品可比的卫生健康科学大数据跨域共享和隐私保护、安全多方计算、安全感知预警等工具软件不少于 10 个;研发医学影像辅助判读、临床电子病历智能化提取和标注等软件工具不少于 10 个;研发融合多源异构卫生健康大数据的知识图谱自动构建工具 1 套,并建立融合不少于 20 个病种的具有高可更新性、可迁移性的知识图谱,有效支撑医学语义搜索、智能问答以及临床决策。研发的软件工具可独立发布部署,形成系列相关专利和软件著作权,并在国家科学数据中心应用部署,在临床、教育、科研等机构推广应用,应用示范单位不少于 20 家。

9.6 面向国家科学数据中心的基础软件栈及系统

研究内容:面向国家科学数据中心实现科学数据的发现、获取、分析、利用等需求,研发自主的科学数据中心基础软件栈及系统;面向科学数据全局可发现和可信共享需求,研究科学数据标识、建模方法和互操作、可信存证技术,支持数据确权和流转追溯;研究面向分析的科学数据加工处理流水线技术,研发面向领域的大数据处理流水线管理调度系统;研发面向多学科跨领域数据的融合管理系统和搜索引擎,支持结构化/非结构化数据的融合存储与查询;面向大数据集成分析需求,研发安全隔离的交互式云分析服务引擎,形成面向领域应用多编程语言、多算法环境、多适配版本的大数据分析环境,为科研人员提供在线编程和在线工作流交互分析服务。

考核指标:构建科学数据与分析软件共享社区,在科学数据的标识、可信存证、跨中心互操作等方面形成一套自主的关键技术与软件体系。标识系统支持国家标准与国际主流科学数据标识的双标识注册解析与服务,系统存证的吞吐能力>10 TPS;数据处理系统具备完整、可追溯的数据汇聚、清洗功能,具备跨中心调度能力,处理性能优于 1000 万行/秒;融合管理系统支持 100 亿级实体和关系、1000 亿级非结构化数据对象的融合存储,提供标准的统一查询语言,科学数据搜索引擎可检索的科学数据集不少于 500 万个,覆盖生物、生态、农业等领域,实体数据量不低于 1PB;软件体系在不少于 5 个国家科学数据中心进行示范应用;在核心技术方向申请专利或软件著作权。

10 科学数据自主应用软件

科学数据自主应用软件研发(青年科学家项目)

研究内容:针对大规模文本、图像、图谱、序列、遥感影像、数值等具有典型特征且在多个领域广泛普适的科学数据类型,面向海量科学数据分析的应用场景,发展数据分析和挖掘技术,开展智能分析挖掘方法的研究,研发具有自主知识产权的软件或软件系统,并在科学数据中心示范应用。

考核指标:由申报单位自主设定。