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Accelerating the process of”the third medical revolution” and a bright future for biomaterials — an interview with minhiro Akaike, Honorary Professor of Tokyo University of Technology

Regenerative medicine is known as the”third medical revolution” after drug treatment and surgical treatment. In recent years, the rapid development of biotechnology and the continuous cross integration and penetration between disciplines have not only promoted the rapid development of regenerative medicine, but also expanded the original regenerative medicine system and promoted the development of regenerative medicine into a new stage.

Regenerative medicine is to repair, replace and enhance damaged, diseased or defective tissues and organs in the human body by activating endogenous stem cells or implanting exogenous stem cells, stem cell derived cells, functional tissues and organs, so as to achieve disease treatment. The development of regenerative medicine brings hope for the cure of a series of major chronic diseases, and also finds potential solutions for the lack of organ sources in organ transplantation. The huge development potential of regenerative medicine makes it a strategic highland for countries all over the world. China, the United States, Japan and the United Kingdom have made a comprehensive layout through a series of comprehensive or special plans. Recently, the instrument information network interviewed Akaike Toshihiro, a famous Japanese cell engineer and honorary professor of Tokyo Institute of technology, and conducted in-depth exchanges on key technologies, major achievements, discipline integration and Sino Japanese academic exchanges in the field of regenerative medicine.

Interview site (first on the left:akichi Minhong, first on the right:Kazuo Zhenzi, researcher)

“Seed” of regenerative medicine — induced pluripotent stem cells

Since the 20th century, regenerative medicine has been a research hotspot in the international biomedical field. It plays an irreplaceable role in ensuring human life and health, improving human quality of life and prolonging human life. Professor Akaike Minhong believes that”the emergence of induced pluripotent stem cells provides a new research direction for the field of stem cell biology and clinical regenerative medicine.” In 2006, Professor Shinya Yamanaka’s research team reprogrammed adult cells into stem cells with pluripotent differentiation potential by transferring retrovirus mediated Oct-4, Sox2, KLF4 and c-myc genes into mouse fibroblasts, and named these stem cells as iPS cells. It is not only expected to avoid moral and ethical disputes, but also from a wide range of sources. Therefore, Professor Nobuyasu Yamanaka won the Nobel Prize in physiology or medicine. This research achievement is also considered by Professor Akaike Minhong as a milestone in the field of regenerative medicine.

The application and innovation of biomaterials in regenerative medicine have epoch-making significance

At present, the research on the functionalization of artificial organs, the development of organ implantation technology and the large-scale culture technology of ES cells, iPS cells and various stem cells in the field of regenerative medicine are lagging behind. Professor Akaike Minhong noticed that biomaterials with cell recognition and functional regulation can be used to culture cells as early as 20 years ago. Many scholars have high hopes for the application of large-scale culture technology and cell differentiation engineering in regenerative medicine in the future. Therefore, Professor Akaike’s team used gene recombination technology to realize the chimerism of the extracellular domain structure of intercellular adhesion molecules and cadherins (E, N, VE, etc.) and the FC tail of antibody molecules, and successfully prepared a non membrane penetrating protein dependent matrix substrate (a cell adsorbent material), which has the functions of cell recognition and function regulation. Through the cultivation of ES cells, iPS cells and various stem cells with this biomaterial, the problems of cell aggregation and easy infection with viruses are overcome, and the large-scale cultivation of iPS cells can be realized, which has a broad application prospect in the field of regenerative medicine. In addition, the biomaterial can even be used as an engineering material for tissue reconstruction, and its future application as a new carrier in regenerative medicine is also worth looking forward to.

When asked about the key scientific instruments used in the research, researcher kazuiko in Professor Akaike’s team focused on the atomic force microscope(Atomic Force MicroscopyAFM)Use of,AFMThe principle is to study the surface structure and properties of substances by detecting the extremely weak interatomic interaction between the surface of the sample to be tested and a micro force sensitive element. Its emergence solves many problems in the research of biomaterials, especially plays an important role in the field of medical applications of biomaterials. It can not only obtain high-resolution images, but also observe the interaction between biomaterials and samples, analyze the mechanical properties of the surface of biomaterials, and even process nano biomaterials at the molecular scale.

Professor Akaike Minhong’s team, researcher Kazuo, used atomic force microscopy to characterize and analyze biomaterials

(author:Teiko Shibata-Seki, Masato Nagaoka, Mitsuaki Goto, Eiry Kobatake, Toshihiro Akaike

(source:DOI:10.1038/s41598-020-72517-2; Scientific Reports volume 10,Article number:17044(2020)

Discipline integration plays a great role in promoting the development of regenerative medicine

Discipline integration plays a great role in promoting regenerative medicine, which has also become the general trend of regenerative medicine and even scientific development. The development of regenerative medicine involves not only the integration of disciplines in the field of life sciences, but also disciplines other than life sciences such as chemistry, physics, engineering, and even social sciences such as economics and ethics, which will have a very important impact on the development of regenerative medicine. Professor Akaike Minhong said”The application and innovation of biomaterials in regenerative medicine requires collaborative work in many fields such as medicine, biology and engineering, and requires the participation of scientific researchers from different disciplines, and the establishment of interdisciplinary research teams with complementary knowledge and technology. Adopting this model is conducive to promoting the overall development of the field in an all-round way, and will also help nurture major breakthroughs. However, at present, in Japan, it is affected by the unbalanced distribution of government research funds and other factors Because of the influence, it is difficult to do this”. In order to overcome the above problems, Professor Akachi Minhong actively carried out academic exchanges with experts and scholars in relevant fields in China, and recognized that the Chinese government attaches great importance to the field of biomaterials and regenerative medicine. Professor Akaike Minhong highly recognized China’s policy of”made in China 2025″ and expressed the hope that his research would be supported by Chinese government funds.

Build a bridge for cross-border academic exchanges and strengthen scientific cooperation between China and Japan

Professor Akaike has a long-standing relationship with China. He has rich scientific research experience in China and regards China as his”second hometown”. During China’s reform and opening up, Professor Akaike Minhong visited China as a Japanese scholar for academic exchanges, discussed cooperation with Chinese experts in various fields, and made a number of Chinese friends, laying the seeds for friendly cooperation and exchanges in the future. In 2005, he participated in the graduate joint training program of Tsinghua University and Tokyo University of technology. As a instructor, he coordinated the exchange of foreign students between China and Japan, and cultivated a large number of talents. In addition, as a visiting professor at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Harbin Medical University and Nankai University, he led many students and scholars to establish a research group on”cell recognition biomaterials”, including two research directions:cadherin modified proteins and sugar chain polymers.

Professor Akaike Minhong believes that the field of regenerative medicine should strengthen exchanges and cooperation between various countries, especially between Japan and China. Only by making friends with young scholars from various countries and absorbing more ideas can we help overcome scientific research problems. China’s development speed is changing with each passing day, and the scientific research level is rapidly improving. A group of outstanding experts and scholars have emerged in the field of regenerative medicine. Professor Akaike Minhong hopes that more young Japanese researchers will participate in the scientific exchanges between China and Japan. This is also the reason why he is very willing and attaches importance to the exchanges with young scholars such as Tsinghua University and Nankai University in China.

Professor Akaike MinhongHe is a famous Japanese cell engineer and an honorary professor at Tokyo Institute of technologyNature Material,JBCAnd other internationally renowned journalseight hundredMore than, apply for invention patentsforty-fiveItem. He firmly believes thatThe future of biomaterials is brightIt is a bridge between medicine, life science and material science. His research work is to develop high qualityESCells andiPS细胞的大规模培养技术为目标,在再生医疗领域取得国内外的广泛关注。Professor Akaike Minhong在中国具有丰富的科研经验,也在中国结交了很多知己,并培养了大量年轻学者和学生,将中国视为自己的Second hometown

2022年7月20日,仪器信息网网络讲堂将再次携手日本分析仪器工业协会(Japan Analytical Instruments Manufacturers Association, JAIMA)共同组织在线科学家论坛“中日科学家论坛——之生命科学”。此次在线科技论坛有幸邀请到Professor Akaike Minhong,将围绕生命科学中的细胞工程、生物材料及其再生医学领域应用、创新细胞分析技术和生物基底材料表征技术等前瞻性领域进行探讨。

The China Japan Forum will be open to the audience for free, and participants can learn knowledge and communicate online with top experts and scholars without leaving home. Sign up for the meetingPlease click on the picture

Interview:liulidong

Written by:Zhao Yiwei