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In depth analysis of Agilent’s four new mass spectrometry products:focusing on intelligence and revolutionary innovation of”hydrogen instead of helium” — two global executives of Agilent’s mass spectrometry division talk about innovation

At this year’s American mass spectrometry Annual Conference (ASMs), Agilent also released four new four-stage rod mass spectrometry products, including a single four-stage rod GC-MS, two triple four-stage rod GC-MS and a triple four-stage rod LC-MS. Recently, sudharshana Seshadri, vice president and general manager of Agilent’s mass spectrometry division, and Dr. Jennifer gushue, associate vice president of mass spectrometry marketing of Agilent’s mass spectrometry division, were interviewed by many media such as the instrument information network on four new products.

The theme of Agilent’s new product release this year is”discover the possibilities”, which means”experiencing the endless possibilities”. In the context of this theme, the two interviewees gave a detailed introduction to the new innovations, innovative ideas and innovative power sources of Agilent mass spectrometry.

Group photo of Agilent mass spectrometry new product release group visit

Gc/ms new product:embrace AI to realize intelligent monitoring, diagnosis and automatic optimization

Jennifer gushue made a detailed introduction to the four new mass spectrometry products released. The first new product, 5977c gc/msd, combines a new intelligent technology – crosslab smart alerts intelligent alarm system. Users can monitor the status of the instrument at any time, learn about the potential problems that may exist in the instrument, reduce downtime, and maximize the analytical performance of the analyzer. In addition to the analytical performance, the analytical flux of the sample is also improved.

Appearance of Agilent 5977c in combination with Agilent 8890 GC

Next, there are two new gc/tq products – 7000E and 7010c. Among them, 7000E is mostly used for routine laboratory analysis, and 7010c can be used in laboratories with high sensitivity requirements. Several intelligent functions are added to the two gc/tq models, such as adaptive swarm autotune, which is an automatic adjustment and optimization function. This function can improve the calibration efficiency. If the analysis process changes the platform, it can well reduce the variability between different instruments, and finally save the analysis time; Another function, advanced system diagnostic, is an advanced system diagnostic function, which can tell the user the potential problems that may occur in the instrument.

Appearance of Agilent 7000E combined with Agilent 8890 GC

Appearance of Agilent 7010c in combination with Agilent 8890 GC

In addition, for these two new products, Agilent also added new acquisition modes, such as triggered multi response detection scanning mode (TMRM), dynamic multi response detection scanning mode (DMRM) and retrospective scanning mode. A variety of selectable modes not only bring higher sensitivity and specificity, but also provide more analytical methods and broader application space.

The first subversive hydro inert ion source:hydrogen can replace helium

In addition to automation and intelligence, the biggest highlight of the three new GC-MS products is a new disruptive technology – Hydro inert ion source.”We found that at present, users of GC/MS are facing a major pain point, that is, helium shortage, rising prices, and the industry believes that the supply of helium will face greater challenges, so many users pay more and more attention to the supply source of gc/ms carrier gas.” Jennifer gushue said,”through this technology, customers can explore using hydrogen instead of helium as the carrier gas for gc/ms analysis.”

According to Dr. Jennifer gushue, the hydro inert ion source is an innovative technology pioneered by Agilent. Such a change is undoubtedly huge for the GC-MS itself. For the problems worried by users, such as the possible changes in performance, operation process and experimental results, Jennifer first eliminated their concerns:the hydro inert ion source will not affect the performance of the instrument. If the user wants to use hydrogen as the carrier gas on other models of gas chromatography-mass spectrometry, he should pay attention to replacing the ion source with Hydro inert ion source, which will not affect the analysis results.

In addition, according to Jennifer gushue, this technology has several advantages:it has better sensitivity than the traditional ion source; Sharp peak shape, no tailing, good spectral fidelity, matching in the ion library, not affected; Hydrogen is a renewable resource, reducing customer costs.

Lc/ms new product:ireflex realizes feedback re injection to avoid experiment repetition and interruption

6475 lc/ms is a new triple four stage rod liquid chromatography mass spectrometry system released this time. Its biggest innovation is also intelligence. In addition to the earlier mentioned early maintenance and early warning functions and swarm autotune functions, the system also has the most critical intelligent Innovation:intelligent reflex (ireflex) function.

Appearance of Agilent 6475 triple quadrupole liquid chromatography mass spectrometry system

How exactly does ireflex help users? Jennifer introduced that in the process of sequential injection, if there is cross contamination, the instrument will inject a single blank sample; If the sample exceeds the range of the standard curve, the injection volume will be automatically reduced to make it return to the range of the standard curve. Moreover, such feedback re injection does not affect the ongoing sequence at all. In a word, ireflex can avoid repeating experiments and interrupting the experimental process.

In addition, 6475 lc/ms also has a variety of MRM scanning modes to support high-throughput analysis. Users can quickly screen and determine whether there are target analytes in turn while performing quantitative analysis, which can greatly shorten the analysis time.

Jennifer gushue also introduced the compliance design of 6475 lc/ms in the pharmaceutical/biopharmaceutical field. In addition to the above features, the customized software on 6475 lc/ms can provide strong traceability and data integrity. The software meets the requirements of FDA 21 CFR Part 1, EU annex 11 and gamp 5. At the same time, many intelligent functions of this new product also meet strict traceability requirements. All functions support relevant data approval, data reporting, user management, secure data storage and secure data archiving.

User demand driven intellectualization and automation become the innovation direction of mass spectrometry

For a long time, in-depth insight into customer needs has been the driving force for Agilent mass spectrometry innovation. Take the biopharmaceutical industry as an example. Biopharmaceutical industry is Agilent’s key strategic field. Agilent has invested a lot of resources in this field, including fully communicating with customers in this field.

On this basis, Agilent mass spectrometry Department summarized their needs into three points:first, mass spectrometry is becoming more and more important in the field of biopharmaceutical, which is due to the dependence of impurity analysis and other processes on mass spectrometry. As biopharmaceutical is a strong regulatory industry, mass spectrometry can help users meet regulatory standards; Second, for the biopharmaceutical industry, speed and timeliness are very important. The excellent reproducibility of mass spectrometry can help users understand whether the development process is moving in the right direction; Third, users have a strong demand for automation technology. They hope to have more automation technology in the R & D process to improve work efficiency.

Intelligence and automation have also become an important innovation direction of Agilent mass spectrometry department. In February this year, Agilent acquired virtual control, a technology company focusing on artificial intelligence. Agilent integrated the acies software developed by Agilent into its gas chromatography mass spectrometry (gs/ms) platform to improve its production capacity, efficiency and accuracy in serving global high-throughput laboratories.

“For users, Agilent’s more intelligent and automated mass spectrometry allows them to focus on the research itself, deal with complex and demanding steps more easily and obtain the desired data. This is the ‘value of time’ we hope to bring to customers.” Sudharshana said.

Agilent mass spectrometry innovation concept:time to value and sustainable development

The so-called”time and half efficiency” is one of Agilent’s innovative mass spectrometry concepts. During the interview, sudharshana Seshadri also introduced to us in detail the innovative concept and original intention of Agilent mass spectrometry department.

“First of all, through close cooperation with customers, it brings time to value.” Sudharshana Seshadri said,”in order to realize ‘time to value’, on the one hand, we are providing reliable and stable technological innovation for customers, and at the same time, we are also trying to provide laboratories with instruments that can quickly produce accurate results and have excellent reproducibility.”

In addition, Agilent also adheres to another important value concept:sustainable development. As early as last year, Agilent announced that it would achieve zero net greenhouse gas emissions by 2050.”As an instrument supplier, we not only have such requirements for ourselves, but also invest a lot of energy in our products, so that our customers can achieve sustainable development. We have cooperated with my green lab, a third-party partner, and many products have passed relevant certifications, which are in line with accountability, consistency and transparency (ACT).” Sudharshana introduced.

The four new mass spectrometry products released this time have well explained these two concepts.

PostscriptDuring the interview, the words”intelligence” and”automation” were mentioned repeatedly. With the in-depth introduction of the two interviewees, the author was deeply impressed by Agilent’s practice of improving experimental efficiency with intelligence. At the same time, the revolutionary innovation of”hydrogen replacing helium as analytical carrier gas” will also become the focus of GC users.

For the Chinese market, the introduction of intelligence is particularly important. China’s inspection and testing market is an emerging market. Its concentration is lower than that of the world. The average laboratory size and personnel experience are in urgent need of development. The intelligence and ease of use of the instrument can reduce the investment required for instrument maintenance and improve the operation efficiency of user laboratories.