Imaging technology has always been an important driving force to promote the development of biomedical field, but in real research, the application of both optical microscope and electron microscope is limited everywhere. Researchers’ research and development from different dimensions of imaging technology has gradually broken the limitations of the current application of imaging technology, making the scientific research path of life science researchers and their practitioners smoother.
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>Chen Liangyi:Professor of Peking University
[personal profile] obtained a bachelor’s degree in biomedical engineering from Xi’an Jiaotong University, a master’s degree in bioelectronics and a doctor’s degree in biomedical engineering from central China University of science and technology. Invent a series of new methods with high spatial-temporal resolution in cell and in vivo imaging. Scientific research achievements were selected into the program sponsored by the Ministry of science and technology“the 13th Five-Year plan“The winner (the highest prize) of the exhibition of scientific and technological innovation achievements and the finals of the”first national disruptive technological innovation competition”.
In 2018, Hessen structured light super-resolution microscope was invented to reduce the phototoxicity of super-resolution imaging by up to three orders of magnitude;two thousand and twenty-twoIn, a new method was further found to break the physical resolution limit of the microscope (“sparse deconvolution super-resolution algorithm”),For the first time in 50 yearsGeneral purpose computational fluorescence super-resolution imaging realizes the super-resolution imaging of living cells with the highest resolution, the fastest speed and the longest imaging time. Also invented live cell fluorescence–Phase bimodal super-resolution microscope, proposed the concept of living cell super-resolution pathology. In addition, a two-photon triaxial scanning light sheet microscope was invented. Together with Academician Cheng Heping, he co invented a series of high-resolution miniaturized two-photon microscopes to observe the morphological and functional changes of a single synapse in free-acting mice for the first time, realizing three-dimensional and multi-layer simultaneous imaging in a large field of vision, and was awarded a Nobel Prize winnerEdvard MoserDoctor called it a”revolutionary” new tool.
>Zhang Yunhai:Deputy Director/researcher of Suzhou Institute of biomedical engineering technology, Chinese Academy of Sciences
[personal profile] researcher and doctoral supervisor of Suzhou Institute of biomedical engineering technology, Chinese Academy of Sciences, and deputy director of Jiangsu Key Laboratory of Medical Optics. His research interests include micro optics and medical optical imaging technology, mainly including confocal imaging, sted super-resolution imaging, two-photon imaging, skin and ophthalmic imaging technology. He has presided over a number of national and provincial key projects, and presided over the development of laser scanning confocal microscope, sted super-resolution microscope, two-photon -sted microscope and other high-end optical microscopes.
> Gao Xiang:associate researcher, Yangtze River Delta Institute of optoelectronics, Peking University
【个人简介】现就职于北京大学长三角光电科学研究院，在高分辨显微成像研究室担任副研究员职务，负责飞秒激光系统创新技术研究及工程化，为High resolution modular microscopic imaging system打造专属的激光光源。2010-2014年在北京大学攻读电子信息科学与技术专业，期间深度参与超短脉冲激光器研究，研发了多个波段的飞秒光纤激光器，并将自主发明的飞秒光纤激光器成功应用于Two photon荧光显微成像系统，为For the first time in the world。 Later, the multi pulse interval scanning image correlation spectroscopy technology was successfully developed, which was used to quantitatively reveal the binding behavior of some receptors and ligands on the cell membrane, and it has application value in drug screening.
> Li Dong:researcher, Institute of Biophysics, Chinese Academy of Sciences
[personal profile] researcher of Institute of Biophysics, Chinese Academy of Sciences, won the national fund for Distinguished Young Scholars, engaged in the development of optical microscopy imaging technology and applied research in life sciences, especially the development of super-resolution fluorescence microscopy imaging technology suitable for living bodies, high speed, long-term and low damage. It pioneered fringe activated nonlinear structured light microscopy, grazing incidence structured light super-resolution microscopy, and Fourier domain attention depth learning super-resolution imaging. Representative works have been published in cell, science, nature methods, molecular cell, developmental cell and other journals.
>Lei Ming:Professor of Xi’an Jiaotong University
[personal profile] Lei Ming, Professor, doctoral supervisor, standing member of the youth Editorial Committee of China laser magazine, deputy leader of the youth working group of the biomedical photonics Professional Committee of the Chinese Optical Society, and director of the microscopic instrument branch of the Chinese instrumentation society. He is mainly engaged in the research of advanced optical imaging and multifunctional optical micromanipulation technology. The problems of cell imaging, special beam optical micromanipulation and nonlinear optical microscopy, which break through the optical diffraction limit, are systematically studied.
> Kong Yu:Director of the electron microscope platform of the center for excellence and innovation in brain science and intelligent technology, Chinese Academy of Sciences
[personal profile] doctor, senior engineer, currently director of the electron microscope technology platform of the center for excellence and innovation in brain science and intelligent technology, Chinese Academy of Sciences, and director of Shanghai Society of microscopy. He has been engaged in the research of neurobiology, electron microscopy and ultrastructure of neural tissue for many years, and has undertaken many projects such as the youth Promotion Association and Shanghai Science and Technology Commission. In recent years, he is mainly engaged in the application of micro brain network structure analysis and reconstruction technology, light microscope and electron microscope combined technology, immune electron microscope technology, etc. in the research of neural loop connection. His technology is comprehensive and experienced, providing a high-level technical support service for the publication of scientific researchers’ papers.
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